A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.
نویسندگان
چکیده
Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 12 شماره
صفحات -
تاریخ انتشار 2005